Table 4: Multivariate analysis to determine relationship of outcome to clinical parameters and molecular subtype classifications in the TCGA-dataset.

In all analyses we performed Cox Proportional Hazards Model with stepwise selection procedure to determine the final model that accurately describes the outcome. The parameters included in each analysis were: Age, sex, T-stage, N-stage, M-stage, LVI, and subtype classification. Only significant parameters based on Wald’s test with overall hazard ratio (HR) and 95% CI are shown.

TCGA dataset OS Indicator
	MCG-1		Consensus		TCGA-2017		Lund-Taxonomy
Parameter	P value	HR; 95% CI	P value	HR; 95% CI	P value	HR; 95% CI	P value	HR; 95% CI
LVI	0.003	2.7; 1.4 – 5.3	0.003	2.7; 1.4 – 5.3	0.016	2.3; 1.2 – 4.7	0.003	2.7; 1.4 – 5.3
Subtype Classification				0.045	4.4; 1.1 – 16.5
TCGA dataset RFS Indicator
	MCG-1		Consensus		TCGA-2017		Lund-Taxonomy
Parameter	P value	HR; 95% CI	P value	HR; 95% CI	P value	HR; 95% CI	P value	HR; 95% CI
N-stage	0.039	2.1; 1.04 – 4.2	0.039	2.1; 1.04 – 4.2	0.039	2.1; 1.04 – 4.2	0.039	2.1; 1.04 – 4.2

Note: Analysis of only HG specimens yields the same values.