Table 2.

Dose modification of first-line antituberculosis drugs in patients with renal dysfunction

Antimycobacterial agent and normal dose	Dosage adjustment according to estimated degree of renal function
	Creatinine clearance 30–60	Creatinine clearance 10–29	Creatinine clearance <10	Intermittent hemodialysis (HD)	Peritoneal dialysis (PD)
Rifampicin 10 mg/kg/day up to 600 mg	No dose adjustment required	No dose adjustment required	No dose adjustment required	No dose adjustment required	No dose adjustment required
Isoniazid 5 mg/kg/day up to 300 mg	No dose adjustment required	No dose adjustment required	No dose adjustment required	No dose adjustment required	No dose adjustment required
Pyrazinamide 30–40 mg/kg/day 1.5 gm for <50 kg 2 gm for <50 kg	No dose adjustment required	30–40 mg/kg q48 hr	30–40 mg/kg three times weekly	30–40 mg/kg three times weekly after dialysis sessions	No dose adjustment required
Ethambutol 15 mg/kg/day	15 mg/kg q24 hr	15 mg/kg q48 hr	15 mg/kg q48 hr	15 mg/kg three times weekly after dialysis sessions	15 mg/kg q48 hr