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. 2021 Jul 30;9(7):e002410. doi: 10.1136/jitc-2021-002410

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Therapeutic efficacy of TCR-T cells in OCI-Ly3 xenograft mouse models. NOG and hIL2-NOG mice were subcutaneously injected with 5×10⁶ HLA*B07:02 expressing OCI-Ly3 cells. Treatment with 1×10⁷ T cells was given by intravenous injection after tumors reached the predetermined size of 100 mm³. (A) Change of tumor volume (significance analysis by two-way ANOVA, showing difference of tumor volume on day 31: ***p<0.001) and survival after treatment start in NOG mice. (B) Change of tumor volume after treatment start in hIL2-NOG mice. Significance analysis by two-way ANOVA, showing difference on day 30: *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. (C) Flow cytometric analysis of T cells in tissues of TCR-T cell-treated common NOG and hIL2-NOG mice, 58 days after treatment. (D) PD-1 expression in TCR-T cells in tissues of hIL2-NOG and common NOG mice on day 58 after treatment start, analyzed by flow cytometry. ANOVA, analysis of variance; IL, interleukin; TCR, T-cell receptor.