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. 2021 Aug;31(8):1325–1336. doi: 10.1101/gr.270371.120

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© 2021 Borsari et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Dynamic localization of ELSs throughout embryonic development. (A) Correlation between ELSs’ sharedness among embryonic samples and frequency of their intergenic localization (error bars represent the 95% confidence interval). (B) MDS representation of embryonic samples defines three main groups of tissues (ESCs in gray; neural progenitors in yellow; more differentiated tissues in green). (C) ELSs specific to neural progenitors and differentiated tissues are more frequently intronic, whereas common ELSs are preferentially intergenic. (D) Dynamics of the localization of active ELSs during ESC-derived maturation stages (hESC, neural progenitors, and neurons). ELSs defined by H3K27ac⁺/H3K4me3⁻ peaks during ESC-derived neural maturation, that also overlap with ENCODE ELSs, increasingly distribute in intronic regions as maturation advances.