Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 19;9:652310. doi: 10.3389/fcell.2021.652310

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Li, Chen, Jiang, Shi, Jiang, Wu, Zhou, Wang, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of ACT on mitochondrial function in LPS-treated BV-2 cells. (A) Ultrastructural changes in the different groups of BV-2 cells under the transmission electron microscopy. a, normal nucleus. b, nucleus chromatin condensation. c, normal mitochondria. d, mitochondrial cristae disarranged or even disappeared. e, swollen and vacuolated mitochondria. (B) The representative images and bar graph of JC-1 red and green fluorescence ratio. (C) Bar graph showing quantified statistics of ATP level. (D) The representative images of DCFH-DA staining and bar graph of intracellular ROS production. (E) ACT distinctly decreases the protein and mRNA levels of PGC-1α. (F) ACT distinctly decreases the protein and mRNA levels of UCP-2. *P < 0.05, **P < 0.01, ***P < 0.005, versus the LPS group. n = 3.

HHS Vulnerability Disclosure