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. 2021 Jul 19;9:652310. doi: 10.3389/fcell.2021.652310

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Copyright © 2021 Li, Chen, Jiang, Shi, Jiang, Wu, Zhou, Wang, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACT bond to and inhibited NF-κB as well as activated AMPKα. (A) ACT distinctly increases the phosphorylation level of AMPKα. (B) The effect of compound C (1 μM) on NO level. ***P < 0.001, versus the LPS group. ##P < 0.01, versus the LPS+ACT group. n = 3. (C) A three-dimensional visual of the binding sites between ACT and NF-κB. (D) A two-dimensional close-up of the molecule binding pocket from the side. (E) Amino acid residues. (F) A three-dimensional visual of the binding sites between ACT and AMPKα. (G) A two-dimensional close-up of the molecule binding pocket from the side. (H) Amino acid residues.

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