Table 2.
Between-Arm Differences in Deterioration of Cognitive Function, QOL, and Symptoms at 6 Months
| Test/Measure and Component | IMRT | PT | P Value | ||
|---|---|---|---|---|---|
| N | % | N | % | ||
| Cognitive function | |||||
| HVLT-R | |||||
| Total Recall | 5 | 21 | 2 | 12 | .68 |
| Delayed Recall | 0 | 0 | 0 | 0 | 1.00 |
| Recognition | 3 | 13 | 2 | 12 | 1.00 |
| TMT | |||||
| Part A | 2 | 8 | 1 | 6 | 1.00 |
| Part B | 4 | 17 | 4 | 24 | .70 |
| COWA | 2 | 8 | 2 | 12 | 1.00 |
| CTB Composite | 19 | 79 | 11 | 65 | .48 |
| EORTC QOL C30 | |||||
| Scale | |||||
| Global HS/QOL | 2 | 9 | 4 | 25 | .21 |
| Physical | 5 | 21 | 2 | 12 | .68 |
| Role | 3 | 13 | 2 | 12 | 1.00 |
| Emotional | 1 | 4 | 1 | 6 | 1.00 |
| Cognitive | 9 | 39 | 3 | 19 | .29 |
| Symptom items | |||||
| Social | 0 | 0 | 1 | 6 | .41 |
| Fatigue | 14 | 58 | 4 | 24 | .05 |
| Nausea/vomiting | 2 | 8 | 1 | 6 | 1.00 |
| Pain | 1 | 4 | 3 | 18 | .29 |
| Dyspnea | 0 | 0 | 2 | 12 | .17 |
| Insomnia | 5 | 21 | 2 | 12 | .68 |
| Appetite loss | 5 | 21 | 1 | 6 | .37 |
| Constipation | 3 | 13 | 4 | 24 | .42 |
| Diarrhea | 3 | 13 | 2 | 13 | 1.00 |
| Financial | 2 | 9 | 2 | 13 | 1.00 |
| BN20 | |||||
| Scale | |||||
| Future uncertainty | 4 | 17 | 2 | 12 | 1.00 |
| Visual disorder | 3 | 13 | 2 | 12 | 1.00 |
| Motor dysfunction | 7 | 29 | 1 | 6 | .11 |
| Comm deficit | 4 | 17 | 4 | 24 | .70 |
| Symptom items | |||||
| Headaches | 3 | 13 | 1 | 6 | .62 |
| Seizures | 1 | 4 | 1 | 6 | 1.00 |
| Drowsiness | 5 | 21 | 6 | 35 | .48 |
| Hair loss | 7 | 29 | 2 | 12 | .26 |
| Itchy skin | 4 | 17 | 3 | 18 | 1.00 |
| Weak legs | 3 | 13 | 1 | 6 | .63 |
| Bladder | 3 | 13 | 1 | 6 | .64 |
| MDASI-BT | |||||
| Subscales | |||||
| Core | 4 | 17 | 1 | 6 | .38 |
| Brain tumor | 3 | 13 | 1 | 6 | .63 |
| Interference | 4 | 17 | 2 | 12 | 1.00 |
| Severity | 4 | 17 | 1 | 6 | .38 |
| Factor groups | |||||
| Constitutional | 4 | 17 | 3 | 18 | 1.00 |
| Cognitive | 5 | 21 | 3 | 18 | 1.00 |
| Interference | 4 | 17 | 2 | 12 | 1.00 |
| Neurologic | 3 | 13 | 2 | 12 | 1.00 |
| Gastrointestinal | 2 | 8 | 4 | 24 | .21 |
| Affective | 6 | 25 | 2 | 12 | .43 |
| Work and walking | 4 | 17 | 2 | 12 | 1.00 |
| Mood-related | 4 | 17 | 4 | 24 | .70 |
Abbreviations: Comm, communication; COWA, Controlled Oral Word Association; CTB, Clinical Trial Battery; EORTC QOL C30, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire C30; HS, health status; HVLT-R, Hopkins Verbal Learning Test-Revised; IMRT, intensity-modulated radiotherapy; MDASI-BT, MD Anderson Symptom Inventory-Brain Tumor module; PT, proton radiotherapy; QOL, quality of life; Recognition, delayed recognition; Symptom interfere, symptom interference; TMT, Trail Making Test.
CTB Composite score is the mean of standardized scores (HVLT-R-Total Recall, HVLT-R-Delayed Recall, HVLT-R-Delayed Recognition, TMT Parts A and B, and COWA). Effective treatment and intent-to-treat analysis had identical results.