Table 3.
CNS WHO Grades of Selected Types, Covering Entities for Which There Is a New Approach to Grading, an Updated Grade, or a Newly Recognized Tumor That Has an Accepted Grade
| CNS WHO Grades of Selected Types | |
|---|---|
| Astrocytoma, IDH-mutant | 2, 3, 4 |
| Oligodendroglioma, IDH-mutant, and 1p/19q-codeleted | 2, 3 |
| Glioblastoma, IDH-wildtype | 4 |
| Diffuse astrocytoma, MYB- or MYBL1-altered | 1 |
| Polymorphous low-grade neuroepithelial tumor of the young | 1 |
| Diffuse hemispheric glioma, H3 G34-mutant | 4 |
| Pleomorphic xanthoastrocytoma | 2, 3 |
| Multinodular and vacuolating neuronal tumor | 1 |
| Supratentorial ependymomaa | 2, 3 |
| Posterior fossa ependymomaa | 2, 3 |
| Myxopapillary ependymoma | 2 |
| Meningioma | 1, 2, 3 |
| Solitary fibrous tumor | 1, 2, 3 |
Grade is based on natural history and for some tumor types, definite grading criteria and understanding of natural history are not yet known. Note the use of Arabic numerals.
aFor morphologically defined ependymomas.