Table 8.

Tumor Types With Revised Nomenclature or Revised Placement in the 2021 WHO Classification of Tumors of the Central Nervous System

Tumor Types With Revised Nomenclature or Revised Placement
Astrocytoma, IDH-mutant (covers grades 2-4; eliminates the term “Glioblastoma, IDH-mutant”)
Diffuse midline glioma, H3 K27-altered (changes “mutant” to “altered” given multiple mechanisms)
Chordoid glioma (removes site designation)
Astroblastoma, MN1-altered (adds genetic modifier)
Supratentorial ependymoma, ZFTA fusion-positive (reflects changes in fusion partner and gene nomenclature; see text)
Embryonal tumor with multilayered rosettes (removes genetic modifier to allow for genetic subtypes)
Malignant melanotic nerve sheath tumor (conforms to terminology in soft tissue pathology literature)
Solitary fibrous tumor (removes the term “hemangiopericytoma” to conform fully with soft tissue pathology nomenclature)
Mesenchymal chondrosarcoma (formerly a subtype)
Adamantinomatous craniopharyngioma (formerly a subtype)
Papillary craniopharyngioma (formerly a subtype)
Pituicytoma, granular cell tumor of the sellar region, and spindle cell oncocytoma (grouped rather than separate)
Pituitary adenoma/PitNET (adds the term “PitNET”)