Table 2.

Regression Coefficients Showing the Adjusted Association Between a Change in the Fazekas Score and Brain Volume on the One Hand, and Changes in Neurocognitive Functioning Domain Scores on the Other Hand, up to 2 Years Posttreatment

	Fazekas Sum Scorea, β	P-value	Brain Atrophyb, β	P-value
Attention/executive functioning	−0.048	.029	−0.212	.505
Information processing	−0.086	.009	−0.753	.095
Memory	−0.050	.165	−0.921	.027
Motor speed	−0.347	.000	−1.774	.163

Correlation coefficients (β) reflect the association between a change in z-score and a change in the sum Fazekas score (max. 30) with 1 point, or a 10% change in brain volume.

^aCorrected for sex, age, education, and multiple lesions at baseline.

^bCorrected for sex, age, education, and multiple lesions and total skull volume at baseline.