Table 2.
30-day complications, by treatment, matched cohort
| Neoadjuvant chemotherapy (n=1,123) | Primary cytoreductive surgery (n= 1,123) | |||||
|---|---|---|---|---|---|---|
| No bowel or upper abdominal procedures (n=796) |
Bowel or upper abdominal procedures (n=327) |
p value | No bowel or upper abdominal procedures (n=580) |
Bowel or upper abdominal procedures (n=543) |
p value | |
| 30-day complications, n (%) | ||||||
| Wound infection | 80 (10.1) | 58 (17.7) | <0.01 | 84 (14.5) | 114 (21.0) | <0.01 |
| Pulmonary embolus/DVT | 92 (11.6) | 37 (11.3) | 0.91 | 53 (9.1) | 62 (11.4) | 0.21 |
| Hematoma/hemorrhage | 196 (24.6) | 93 (28.4) | 0.18 | 135 (23.3) | 147 (27.1) | 0.14 |
| Other surgical complications* | 222 (27.9) | 169 (51.7) | <0.01 | 217 (37.4) | 320 (58.9) | <0.01 |
| Cardiac | 106 (13.3) | 61 (18.7) | 0.02 | 92 (15.9) | 112 (20.6) | 0.04 |
| Respiratory | 136 (17.1) | 101 (30.9) | <0.01 | 188 (32.4) | 243 (44.8) | <0.01 |
| Acute renal failure | 31 (3.9) | 25 (7.6) | <0.01 | 47 (8.1) | 45 (8.3) | 0.91 |
| Shock | 40 (5.0) | 33 (10.1) | <0.01 | 51 (8.8) | 54 (9.9) | 0.51 |
| Fluid/electrolyte imbalances | 211 (26.5) | 114 (34.9) | <0.01 | 178 (30.7) | 202 (37.2) | 0.02 |
| Other infections** | 77 (9.7) | 68 (20.8) | <0.01 | 88 (15.2) | 129 (23.8) | <0.01 |
| Emergency Room Visit | 105 (13.2) | 67 (20.5) | <0.01 | 111 (19.1) | 163 (30.0) | <0.01 |
| ICU Stay | 14 (1.8) | 12 (3.7) | 0.05 | ---*** | 25 (4.6) | <0.01 |
| Hospital readmission | 121 (15.2) | 81 (24.8) | <0.01 | 120 (20.7) | 140 (25.8) | 0.04 |
Bold indicates statistical significance with a p<0.05
*
Peritonitis, reopening laparotomy, surgical complication NOS, injury to vessel of abdomen/pelvis, suture or laceration of ureter, foreign body, stoma complications
**
Pneumonia/respiratory infection, sepsis/bacteremia, urinary tract infection, Clostridium difficile
***
Censored due to small cell size to protect patients’ confidentiality