Table 2.
Main causes of non-CF bronchiectasis and associated CT features
| Causes | Type of bronchiectasis | Distribution | Associated and/or distinctive features |
|---|---|---|---|
| Congenital | |||
| Mounier-Kuhn Syndrome77 | NA (Trachea and main bronchi) |
Central lung regions | Bronchial diverticulosis, tracheal diverticula |
| Williams-Campbell Syndrome78 | Varicose, cystic | Sub segmental bronchi (fourth to sixth generations) |
Collapsed bronchi and distal air-trapping on expiratory CT |
| α 1-Antitrypsin deficiency79 | Cylindric, cystic | Mainly lower lobe | Panlobular emphysema |
| Immunologic | |||
| Allergic bronchopulmonary aspergillosis16 | Cylindric, varicose | Segmental and subsegmental bronchi of central-upper lungs regions | Mucous plugging (“finger-in-glove” sign) |
| Infectious or inflammatory | |||
| Bacterial, mycobacterial, viral | Various | Various | Depend on pathogens |
| Swyer-James Syndrome80 | Cylindric | Non-specific | Hyperlucent lobe or lung and air-trapping |
| Chronic aspiration80 | Cylindric | Basal lung regions | Bronchial wall thickening, tree-in-bud consolidations |
| Defective mucous transport | |||
| Primary Ciliary Dyskinesia81 | Varicose, cylindric | Middle and lower lobes | Situs inversus |
| Young’s Syndrome82 | Cystic | Little evidence | Little evidence |
| Primary immunodeficiency83 | Mainly cylindric | Upper and mid lung regions | Non-specific |
| Airways obstruction | |||
| Endobronchial malignancies75 | Various | Focal | Various |
| Broncholithiasis80 | Cylindric, varicose | Focal, more often middle lobe | Calcified lymph nodes |
| Extrinsic compression75 | Various | Focal | Various |
| Idiopathic | Various | Basal lung regions20 | Various |