TABLE 1.

k_inact/K_i and k_off of durlobactam and k_inact/K_i for avibactam with β-lactamases^a.

Class	β -Lactamase	Durlobactam	Durlobactam	Avibactam
		kinact/Ki (M–1 s–1)	koff (s–1)	kinact/Ki (M–1 s–1)
A	CTX-M-15	7 (±2) × 106	2.2 (±0.5) × 10–4	8 × 105
A	SHV-5	6.4 (±0.5) × 106	5.5 (±0.3) × 10–4	1 × 105
A	TEM-1	1.4 (±0.6) × 107	1.4 (±0.2) × 10–3	4 × 105
A	KPC-2	9.3 (±0.6) × 105	1.0 (±0.1) × 10–3	6 × 103
A	KPC-3	8 (±1) × 105	2.7 (±0.7) × 10–4	7.1 (± 0.7) × 103
C	Pseudomonas aeruginosa AmpC	9 (±5) × 105	4 (±1) × 10–3	3 × 103
C	Enterobacter cloacae P99	2.3 (±0.4) × 106	3.4 (±0.1) × 10–4	8 × 103
C	Acinetobacter baumannii ADC-7	1.0 (±0.1) × 106	8 (±1) × 10–4	NT
D	OXA-10	9 (±2) × 103	3.4 (±0.1) × 10–6	70
D	OXA-23	5.1 (±0.2) × 103	1.10 (±0.04) × 10–5	100
D	OXA-24	9 (±2) × 103	1.7 (±0.1) × 10–5	80
D	OXA-48	8 (±2) × 105	2.5 (±0.3) × 10–5	5 × 103
D	OXA-58	2.5 (±0.3) × 105	1.6 (±0.3) × 10–4	120 ± 40
D	OXA-66	6 (±0.7) × 102	NT	NT

^aValues shown are averages ± standard deviations, or single measurements. The k_inact/K_i parameter is described in Tonge (2019). Measurements are from Durand-Reville et al. (2017), Shapiro and Gao (2021); Shapiro et al. (2021),Barnes et al. (2019) and Vázquez-Ucha et al. (2017). NT, not tested.