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. Author manuscript; available in PMC: 2021 Aug 2.
Published in final edited form as: J Pathol. 2019 Nov 29;250(2):148–158. doi: 10.1002/path.5353

Figure 3.

Figure 3.

Multifocal heterogeneity of KRAS mutation status (case #11). (A) Digital scan (1×) showing metastatic LGSC involving omentum and separate foci of endosalpingiosis. Note that for Es #2, the two adjacent cystic structures merge into a single cyst on deeper sections. (B–D) Lesions from (A) at 40×. (E) Multiplex KRAS mutation ddPCR screening assay for lesions isolated by laser-capture microdissection. (F) KRASG12D and KRASG12V ddPCR assays reveal the presence of both mutant alleles in Es #2.