TABLE 4.

Key Points in AF and Women

Stroke Prevention in AF in Women	(Ref. #)	First Author (Year)
Female sex is a risk modifier and adding female sex to the CHA2DS2-VASc score matters for age >65 yrs or >2 non-sex-related stroke risk factors.	(107)	Nielsen et al. (2018)
Women with AF have a greater stroke severity and worse long-term outcome in terms of permanent disability, compared with men with AF.	(108,111)	Linde et al. (2018); Martin et al. (2017)
Women with AF have a greater residual stroke risk even with well-controlled VKAs, which was not seen in randomized controlled trials of the novel anticoagulants.	(109,110)	Sullivan et al. (2012); Pancholy et al. (2014)
Women taking novel anticoagulants have lower major bleeding rates compared with men.	(108)	Linde et al. (2018)
There were no significant differences among the novel anticoagulants in terms of safety and efficacy for women.	(112)	Moseley et al. (2017)

AF = atrial fibrillation; VKA = vitamin K antagonist.