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. 2021 Apr 9;31(9):4151–4168. doi: 10.1093/cercor/bhab075

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Phenome-wide association analysis for horizontal brain skew. (A) Manhattan plots for the associations. Red lines indicate the Bonferroni corrected threshold (P < 1.40e−05). (B) Significant associations of skew measures with regional gray matter volumes. Red–yellow indicates a positive association; blue indicates a negative association. (C) Significant associations of skews with various white matter metrics. Red indicates a positive association; blue indicates a negative association. The per-region names and statistics for parts (B) and (C) can be found in Supplementary Dataset S1. FA: fractional anisotropy, MD: mean diffusivity, L1/L2/L3: the 3 eigenvalues of diffusion, MO: mode of anisotropy, OD: orientation dispersion, ICVF: intra-axonal volume fraction, ISOVF: isotropic volume fraction.