Table 3.
Major parameters from the enhanced path model in males
| Variable | Total effect | Total indirect effect | Major mediating variables |
|---|---|---|---|
| AUD GRS | 0.17 (0.16, 0.19) | 0.05 (0.05, 0.06) | Externalizing PP, |
| externalizing Sxs | |||
| Internalizing Sxs | 0.15 (0.15, 0.16) | 0.15 (0.15, 0.16) | Externalizing Sxs, |
| alcohol use | |||
| Externalizing Sxs | 0.36 (0.34, 0.37) | 0.36 (0.34, 0.37) | Externalizing PP, alcohol use |
| Drug use | 0.11 (0.08, 0.13) | 0.03 (0.02, 0.03) | Alcohol use |
| Alcohol use | 0.17 (0.014, 0.19) | 0.00 (0.00, 0.00) | – |
| Low IQ | 0.05 (0.04, 0.06) | 0.05 (0.04, 0.06) | Low educ. att., |
| externalizing PP | |||
| Low resilience | 0.00 (0.00, 0.01) | 0.00 (0.00, 0.01) | Low educ. att. |
| Externalizing PP | 0.27 (0.24, 0.29) | 0.00 (0.00, 0.00) | – |
| Low educ. att. | 0.07 (0.06, 0.09) | – | |
| RMSEA | 0.042 (0.041, 0.04) | ||
| R2 | 21.5% | ||
| TLI | 0.963 | ||
| CFI | 0.966 |
Notes: AUD GRS = alcohol use disorder genetic risk score; PP = psychopathology; Sxs = symptoms; educ. att. = educational attainment; RMSEA = root mean square error of approximation; TLI = Tucker–Lewis index; CFI = comparative fit index.