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. 2021 Aug 2;16(8):e0255155. doi: 10.1371/journal.pone.0255155

Fig 3. Cytokines and chemokines in the perfusate.

Fig 3

After 4 hours of EVLP, concentrations of chemokines MIP1α (Fig 3A) and MIP2 (Fig 3B) collected from the 28°C, 24°C and 21°C conditions were significantly lower than at 37°C (p<0.05 to p<0.01). Concentrations of GRO-α (Fig 3C) and IL-6 (Fig 3D) collected from all the subnormothermic conditions were significantly lower than at 37°C (p<0.05 to p<0.01). Concentration of IL-18 (Fig 3E) at 21°C was significantly lower than at 37°C (p<0.05), whereas IL-18 levels detected at 24°C, 28°C and 32°C were lower but not significantly different from levels observed at 37°C. Concentrations of IL-1β (Fig 3F) at 21°C and 24°C were lower than at 37°C (p<0.01). For IL-1α (Fig 3G), MCP-1 (Fig 3H) and VEGF (Fig 3I), their concentrations showed lower values compared to 37°C.