Table 4. Pre Compression evaluation of liquisolid compacts containing clopidogrel.
Formulation Code | Bulk Volume (mL) | Tapped Volume (mL) | Bulk Density (g/mL) | Tapped Density (g/mL) | Hausner Ratio | Carr’s Index (%) | Angle of Repose (o) |
---|---|---|---|---|---|---|---|
Control Formulation | 25.00 | 16.59 | 0.33 | 0.49 | 1.48 | 32.65 | 35.80 |
LSC-01 | 25.00 | 20.00 | 0.57 | 0.71 | 1.25 | 20.00 | 33.76 |
LSC-02 | 25.00 | 17.50 | 0.43 | 0.61 | 1.41 | 29.50 | 30.09 |
LSC-03 | 25.00 | 19.00 | 0.42 | 0.55 | 1.31 | 23.92 | 29.82 |
LSC-04 | 25.00 | 19.50 | 0.59 | 0.76 | 1.28 | 21.99 | 34.66 |
LSC-05 | 25.00 | 19.50 | 0.61 | 0.78 | 1.28 | 22.00 | 30.93 |
LSC-06 | 25.00 | 18.00 | 0.48 | 0.67 | 1.39 | 28.00 | 30.17 |
LSC-07 | 25.00 | 17.50 | 0.43 | 0.61 | 1.43 | 30.00 | 32.42 |
LSC-08 | 25.00 | 17.50 | 0.43 | 0.62 | 1.43 | 29.99 | 29.13 |
LSC-09 | 25.00 | 17.00 | 0.43 | 0.63 | 1.47 | 32.00 | 31.59 |
LSC-10 | 25.00 | 17.60 | 0.34 | 0.48 | 1.41 | 29.17 | 30.69 |
LSC-11 | 25.00 | 19.00 | 0.45 | 0.60 | 1.00 | 23.99 | 32.37 |
LSC-12 | 25.00 | 19.00 | 0.52 | 0.67 | 1.32 | 23.99 | 36.31 |
Data is presented as mean of triplicate determination (n = 3).
Data has been rounded to two digits after decimal point.