. Author manuscript; available in PMC: 2021 Aug 2.

Published in final edited form as: J Immunol. 2020 Jun 3;205(1):143–152. doi: 10.4049/jimmunol.1901289

Table 1:

Virus infection in fetus from clodronate and control-liposomes treated dams.

Tissue Region^a	Control liposome	Clodronate liposome
Whole fetus	5/13 (38.5 %)	21/26 (80.8%)
Lymph node	2/13 (15.4%)	13/26 (50.0%)
Nasal turbinates	3/13 (23.1%)	15/26 (57.7%)
Choroid plexus	1/13 (7.7%)	8/26 (30.8%)
Meningies	2/13 (15.4%)	10/26 (38.5%)
Head neck	5/13 (38.5%)	14/26 (53.8%)
Brain	1/11 (9.1%)	12/23 (52.2%)
Spinal cord	0/11	5/23 (26.1%)
Muscle	0/13	4/26 (15.4%)
Plural organs^b	0/13	4/26 (15.4%)
Abdominal organs^c	0/13	5/26 (15.4%)

^a.

all determinations of tissue infection were determined by anatomical reference { http://www.emouseatlas.org } and did not involve immunohistochemical phenotyping except for lymphatics which were determined by Iba1+ labeling

^b.

indicates if ZIKV antigen was observed in any organ within the plural cavity

^c.

indicates if ZIKV antigen was observed in any organ within the abdominal cavity