Figure 3.

Chemical structures and binding of covalent BTK inhibitors, (A) ibrutinib (5p9j), and (B) zanubrutinib (6j6m). Residues within 5 Å distance from inhibitor are shown in green. Atoms in the inhibitors are colored based on the elements, carbon gray, nitrogen blue, oxygen red. Covalent bond between C481 and inhibitor is in magenta. The structures have the same pose as in Figure 2C .