Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Loss- and gain-of-function variations in BTK kinase domain. (A) XLA-causing variants (cyan) are distributed all along the kinase domain. (B) Sites of ibrutinib resistance conferring amino acids C481 (red) and T474 (green) along with gain-of-function variants at positions 512, 513, 517 and 547 (yellow), note that variant at 474 alone and together with other variants lead to gain-of-function activities. The structures are for ibrutinib (pink) complex with BTK (5p9j).
