Table 5.
Relationship between aPL with LA and risk of ANY thrombosis
| Antibody combinations | No. of events | Person- years | Rate (per 1000 person-years) | Age-adj. RR (95% CI) | P-value | |
|---|---|---|---|---|---|---|
| (1) LA and aCL-G | LA (+), aCL-G (−) | 11 | 232 | 47.4 | 1.00 (ref) | |
| LA (+), aCL-G (+) | 3 | 86 | 34.7 | 0.76 (0.21, 2.74) | 0.6715 | |
| LA (-), aCL-G (+) | 1 | 181 | 5.5 | 0.12 (0.02, 0.93) | 0.042 | |
| LA (-), aCL-G (−) | 73 | 5754 | 12.7 | 0.27 (0.14, 0.51) | <0.0001 | |
| (2) LA and aCL-M | LA (+), aCL-M (−) | 12 | 254 | 47.2 | 1.00 (ref) | |
| LA (+), aCL-M (+) | 2 | 64 | 31.2 | 0.63 (0.14, 2.85) | 0.5537 | |
| LA (−), aCL-M (+) | 1 | 190 | 5.3 | 0.11 (0.01, 0.84) | 0.0334 | |
| LA (−), aCL-M (−) | 73 | 5746 | 12.7 | 0.26 (0.14, 0.49) | <0.0001 | |
| (3) LA and aCL-A | LA (+), aCL-A (−) | 13 | 303 | 42.9 | 1.00 (ref) | |
| LA (+), aCL-A (+) | 1 | 16 | 64.1 | 1.42 (0.18, 11) | 0.7352 | |
| LA (−), aCL-A (+) | 1 | 29 | 33.9 | 0.74 (0.1, 5.74) | 0.7739 | |
| LA (−), aCL-A (−) | 73 | 5906 | 12.4 | 0.29 (0.16, 0.52) | <0.0001 | |
| (4) LA and aB2GPI-G | LA (+), aB2GPI-G (−) | 11 | 246 | 44.7 | 1.00 (ref) | |
| LA (+), aB2GPI-G (+) | 3 | 72 | 41.4 | 0.96 (0.27, 3.46) | 0.9481 | |
| LA (−), aB2GPI-G (+) | 1 | 126 | 7.9 | 0.18 (0.02, 1.39) | 0.1000 | |
| LA (−), aB2GPI-G (−) | 73 | 5810 | 12.6 | 0.28 (0.15, 0.53) | <0.0001 | |
| (5) LA and aB2GPI-M | LA (+), aB2GPI-M (−) | 11 | 234 | 47.1 | 1.00 (ref) | |
| LA (+), aB2GPI-M (+) | 3 | 85 | 35.4 | 0.73 (0.2, 2.64) | 0.6333 | |
| LA (−), aB2GPI-M (+) | 6 | 612 | 9.8 | 0.2 (0.08, 0.56) | 0.0018 | |
| LA (−), aB2GPI-M (−) | 68 | 5324 | 12.8 | 0.27 (0.14, 0.51) | <0.0001 | |
| (6) LA and aB2GPI-A | LA (+), aB2GPI-A (−) | 7 | 220 | 31.8 | 1.00 (ref) | |
| LA (+), aB2GPI-A (+) | 7 | 98 | 71.4 | 2.28 (0.8, 6.52) | 0.1253 | |
| LA (−), aB2GPI-A (+) | 13 | 709 | 18.3 | 0.58 (0.23, 1.45) | 0.2438 | |
| LA (−), aB2GPI-A (−) | 61 | 5227 | 11.7 | 0.37 (0.17, 0.8) | 0.0119 | |
aCL-G: aCL IgG; aCL-M: aCL IgM; aCL-A: aCL IgA; aB2GPI-G: anti-β2-glycoprotein I IgG; aB2GPI-M: anti-β2-glycoprotein I IgM; aB2GPI-A: anti-β2-glycoprotein I IgA; age-adj. RR: age-adjusted rate ratio.