Table 1.

Binding affinities to the SARS-CoV-2 M^pro in comparison with danoprevir, lopinavir, and ritonavir

No.	Name of the Ligand	Binding Free Energy (kcal/mol)
1	24(OH)L3	−8.3
2	25(OH)L3	−8.0
3	20S(OH)7DHC	−8.0
4	22R(OH)7DHC	−7.8
5	20S(OH)L3	−7.8
6	25(OH)7DHC	−7.7
7	1,25(OH)2D3	−7.6
8	20S(OH)D3	−7.6
9	7-DHP	−7.5
10	25(OH)D3	−7.3
11	Danoprevir	−8.5
12	Lopinavir	−8.3
13	Ritonavir	−7.2