Figure 4.
Protein-protein interaction (PPI) network construction and topology analysis. (a) The PPI network of AR-PN herb pair putative targets. (b) The PPI network of DN-related DEGs. (c) The interactive PPI network of AR-PN herb pair putative targets and DN-related DEGs. (d) The PPI network of significant proteins screened from (c). (e) The PPI network of candidate targets of AR-PN herb pair against DN screened from (d). BC: betweenness centrality; CC: closeness centrality; DC: degree centrality; DEGs: differentially expressed genes.