Table 2.
The information of 115 candidate targets.
| No. | Genes | Protein name | Betweenness centrality | Closeness centrality | Degree |
|---|---|---|---|---|---|
| 1 | NTRK1 | Neurotrophic receptor tyrosine kinase 1 | 0.05711884 | 0.56600852 | 1199 |
| 2 | TP53 | Tumor protein p53 | 0.02958689 | 0.5339014 | 768 |
| 3 | APP | Amyloid-beta precursor protein | 0.04325808 | 0.53585828 | 746 |
| 4 | CUL3 | Cullin 3 | 0.01621362 | 0.52767084 | 744 |
| 5 | EGFR | Epidermal growth factor receptor | 0.03631785 | 0.53435673 | 738 |
| 6 | MCM2 | Minichromosome maintenance complex component 2 | 0.01374128 | 0.52022299 | 639 |
| 7 | ESR1 | Estrogen receptor 1 | 0.01715955 | 0.52376403 | 634 |
| 8 | XPO1 | Exportin 1 | 0.02022198 | 0.52090261 | 631 |
| 9 | FN1 | Fibronectin 1 | 0.01700008 | 0.51837844 | 612 |
| 10 | UBC | Ubiquitin C | 0.01612385 | 0.52282751 | 583 |
| 11 | CDK2 | Cyclin-dependent kinase 2 | 0.01028813 | 0.50905292 | 554 |
| 12 | COPS5 | COP9 signalosome subunit 5 | 0.00808418 | 0.51083159 | 517 |
| 13 | CUL7 | Cullin 7 | 0.0048695 | 0.50431183 | 515 |
| 14 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | 0.0130468 | 0.5220807 | 510 |
| 15 | GRB2 | Growth factor receptor bound protein 2 | 0.01540288 | 0.51268264 | 485 |
| 16 | RNF2 | Ring finger protein 2 | 0.00618846 | 0.4979564 | 484 |
| 17 | MYC | V-myc avian myelocytomatosis viral oncogene homolog | 0.01293694 | 0.50705202 | 482 |
| 18 | SIRT7 | Sirtuin 7 | 0.00526073 | 0.49220065 | 470 |
| 19 | CUL1 | Cullin 1 | 0.00576927 | 0.50257821 | 469 |
| 20 | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | 0.00881384 | 0.51503053 | 466 |
| 21 | OBSL1 | Obscurin-like 1 | 0.00370032 | 0.49442002 | 454 |
| 22 | CAND1 | Cullin-associated and neddylation dissociated 1 | 0.00443969 | 0.49280899 | 450 |
| 23 | NPM1 | Nucleophosmin | 0.00555129 | 0.51059371 | 447 |
| 24 | ITGA4 | Integrin subunit alpha 4 | 0.00477184 | 0.49671574 | 444 |
| 25 | VCP | Valosin-containing protein | 0.00713559 | 0.51005931 | 413 |
| 26 | CCDC8 | Coiled-coil domain containing 8 | 0.00480319 | 0.49453151 | 412 |
| 28 | EP300 | E1A binding protein p300 | 0.00792101 | 0.50367478 | 410 |
| 27 | HSP90AB1 | Heat shock protein 90 alpha family class B member 1 | 0.00696006 | 0.51089109 | 410 |
| 29 | VCAM1 | Vascular cell adhesion molecule 1 | 0.0048008 | 0.4901654 | 404 |
| 30 | CDC5L | Cell division cycle 5 like | 0.00445741 | 0.4891268 | 399 |
| 31 | FBXO6 | F-box protein 6 | 0.00660866 | 0.4884731 | 393 |
| 32 | BRCA1 | BRCA1, DNA repair associated | 0.00689339 | 0.49897611 | 391 |
| 33 | TRAF6 | TNF receptor-associated factor 6 | 0.00575486 | 0.49914647 | 378 |
| 34 | HNRNPU | Heterogeneous nuclear ribonucleoprotein U | 0.00359109 | 0.49694086 | 371 |
| 35 | SNW1 | SNW domain containing 1 | 0.00370573 | 0.49164892 | 370 |
| 36 | HDAC1 | Histone deacetylase 1 | 0.00504406 | 0.48798398 | 362 |
| 37 | EED | Embryonic ectoderm development | 0.00288746 | 0.47673913 | 359 |
| 38 | HUWE1 | HECT, UBA, and WWE domain containing 1, E3 ubiquitin protein ligase | 0.00326087 | 0.49508974 | 358 |
| 39 | EWSR1 | EWS RNA binding protein 1 | 0.00617052 | 0.49931694 | 356 |
| 40 | HNRNPA1 | Heterogeneous nuclear ribonucleoprotein A1 | 0.00376562 | 0.49660326 | 352 |
| 41 | MDM2 | MDM2 proto-oncogene | 0.0054897 | 0.49744811 | 346 |
| 42 | UBE2I | Ubiquitin conjugating enzyme E2 I | 0.00515795 | 0.4938077 | 344 |
| 43 | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta | 0.00453158 | 0.49643463 | 338 |
| 47 | RPA1 | Replication protein A1 | 0.00447185 | 0.4904943 | 329 |
| 46 | VHL | Von Hippel-Lindau tumor suppressor | 0.0044112 | 0.49126344 | 329 |
| 44 | PARK2 | Parkin RBR E3 ubiquitin protein ligase | 0.00331119 | 0.48923592 | 329 |
| 45 | HSPA5 | Heat shock protein family A (Hsp70) member 5 | 0.002573 | 0.50292398 | 329 |
| 48 | HDAC5 | Histone deacetylase 5 | 0.00203062 | 0.48282695 | 327 |
| 49 | HIST1H3E | Histone cluster 1 H3 family member e | 0.00117386 | 0.4791348 | 320 |
| 50 | HIST1H3B | Histone cluster 1 H3 family member b | 0.00117386 | 0.4791348 | 320 |
| 51 | HIST1H3G | Histone cluster 1 H3 family member g | 0.00117386 | 0.4791348 | 320 |
| 52 | HIST1H3C | Histone cluster 1 H3 family member c | 0.00117386 | 0.4791348 | 320 |
| 53 | HIST1H3H | Histone cluster 1 H3 family member h | 0.00117386 | 0.4791348 | 320 |
| 54 | HIST1H3J | Histone cluster 1 H3 family member j | 0.00117386 | 0.4791348 | 320 |
| 55 | HIST1H3A | Histone cluster 1 H3 family member a | 0.00117386 | 0.4791348 | 320 |
| 56 | HIST1H3D | Histone cluster 1 H3 family member d | 0.00117386 | 0.4791348 | 320 |
| 57 | HIST1H3I | Histone cluster 1 H3 family member i | 0.00117386 | 0.4791348 | 320 |
| 58 | HIST1H3F | Histone cluster 1 H3 family member f | 0.00117386 | 0.4791348 | 320 |
| 59 | HSPB1 | Heat shock protein family B (small) member 1 | 0.00950276 | 0.49475465 | 319 |
| 60 | HSPA8 | Heat shock protein family A (Hsp70) member 8 | 0.00598969 | 0.50361695 | 312 |
| 61 | SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 0.00389245 | 0.50017106 | 312 |
| 62 | RPA2 | Replication protein A2 | 0.00253078 | 0.48961822 | 310 |
| 63 | CUL2 | Cullin 2 | 0.00217148 | 0.48171334 | 309 |
| 64 | CTNNB1 | Catenin beta 1 | 0.00495783 | 0.5011426 | 304 |
| 65 | EEF1A1 | Eukaryotic translation elongation factor 1 alpha 1 | 0.00334497 | 0.49660326 | 304 |
| 66 | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | 0.00349418 | 0.49570524 | 300 |
| 67 | AKT1 | AKT serine/threonine kinase 1 | 0.00665037 | 0.49682827 | 296 |
| 68 | AR | Androgen receptor | 0.00533699 | 0.49264293 | 294 |
| 70 | CREBBP | CREB binding protein | 0.00344521 | 0.47960634 | 292 |
| 69 | U2AF2 | U2 small nuclear RNA auxiliary factor 2 | 0.00188521 | 0.4802365 | 292 |
| 71 | IKBKG | Inhibitor of nuclear factor kappa B kinase subunit gamma | 0.00421812 | 0.49126344 | 291 |
| 72 | MAPK1 | Mitogen-activated protein kinase 1 | 0.00590832 | 0.493086 | 287 |
| 73 | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon | 0.00319492 | 0.49253229 | 283 |
| 74 | PAN2 | PAN2 poly(A) specific ribonuclease subunit | 0.00154999 | 0.46525936 | 281 |
| 75 | SUZ12 | SUZ12 polycomb repressive complex 2 subunit | 0.00168493 | 0.46605037 | 279 |
| 76 | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon | 0.00234006 | 0.47493232 | 276 |
| 77 | ARRB2 | Arrestin beta 2 | 0.00295499 | 0.48351891 | 274 |
| 78 | CUL5 | Ccullin 5 | 0.00161801 | 0.47421343 | 274 |
| 79 | FUS | FUS RNA binding protein | 0.00199535 | 0.48673843 | 271 |
| 80 | SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.00239525 | 0.48288011 | 270 |
| 81 | RPA3 | Replication protein A3 | 0.00151664 | 0.47575659 | 268 |
| 82 | STAU1 | Staufen double-stranded RNA binding protein 1 | 0.00121324 | 0.47908247 | 261 |
| 83 | RELA | RELA proto-oncogene, NF-kB subunit | 0.00499948 | 0.48700866 | 260 |
| 84 | GSK3B | Glycogen synthase kinase 3 beta | 0.00641109 | 0.48641455 | 256 |
| 85 | SMAD3 | SMAD family member 3 | 0.00358228 | 0.48956357 | 255 |
| 86 | BMI1 | BMI1 proto-oncogene, polycomb ring finger | 0.00156804 | 0.46619898 | 254 |
| 87 | COMMD3-BMI1 | COMMD3-BMI1 readthrough | 0.00156804 | 0.46619898 | 254 |
| 88 | BAG3 | BCL2-associated athanogene 3 | 0.00385077 | 0.47819451 | 252 |
| 89 | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta | 0.00260668 | 0.48722506 | 250 |
| 90 | HSPA4 | Heat shock protein family A (Hsp70) member 4 | 0.00289896 | 0.49548125 | 248 |
| 91 | PARP1 | Poly(ADP-ribose) polymerase 1 | 0.00322874 | 0.48086833 | 247 |
| 92 | SMAD2 | SMAD family member 2 | 0.00305262 | 0.48002627 | 246 |
| 93 | RPS27A | Ribosomal protein S27a | 0.00243271 | 0.4884731 | 246 |
| 94 | FLNA | Filamin A | 0.00324118 | 0.4884731 | 245 |
| 95 | MYH9 | Myosin heavy chain 9 | 0.00289354 | 0.48673843 | 244 |
| 96 | CDKN1A | Cyclin-dependent kinase inhibitor 1A | 0.00408751 | 0.48123766 | 241 |
| 98 | ACTB | Actin beta | 0.00348475 | 0.49325236 | 238 |
| 97 | TARDBP | TAR DNA binding protein | 9.56E-04 | 0.47436729 | 238 |
| 99 | HDAC2 | Histone deacetylase 2 | 0.00315062 | 0.47055037 | 236 |
| 100 | ABL1 | ABL proto-oncogene 1, nonreceptor tyrosine kinase | 0.00149438 | 0.49076871 | 236 |
| 101 | CUL4B | Cullin 4B | 0.00369003 | 0.47788189 | 234 |
| 102 | FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.00105834 | 0.46619898 | 234 |
| 103 | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.00157335 | 0.46884019 | 233 |
| 104 | CRK | CRK proto-oncogene, adaptor protein | 0.00664489 | 0.48218997 | 232 |
| 105 | PRKCA | Protein kinase C alpha | 0.00314723 | 0.47971125 | 232 |
| 107 | ARRB1 | Arrestin beta 1 | 0.00432736 | 0.48018393 | 231 |
| 106 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit | 0.00304336 | 0.47762169 | 231 |
| 108 | TUBB | Tubulin beta class I | 0.00214432 | 0.49464306 | 231 |
| 109 | HNRNPK | Heterogeneous nuclear ribonucleoprotein K | 0.00139431 | 0.48787542 | 230 |
| 110 | RPL10 | Ribosomal protein L10 | 0.0011806 | 0.46314678 | 229 |
| 112 | CLTC | Clathrin heavy chain | 0.00232751 | 0.48652246 | 228 |
| 111 | FBXW11 | F-box and WD repeat domain containing 11 | 0.00221635 | 0.47298609 | 228 |
| 113 | HLA-B | Major histocompatibility complex, class I, B | 0.00338256 | 0.45549901 | 227 |
| 114 | PRKDC | Protein kinase, DNA-activated, catalytic polypeptide | 0.00185628 | 0.48950893 | 227 |
| 115 | BTRC | Beta-transducin repeat-containing E3 ubiquitin protein ligase | 0.00175312 | 0.47793397 | 227 |