Table 2.

Efficacy of injectable paromomycin.

Author	Year	Dose and duration	Initial efficacy (at the end of treatment)	Final efficacy (at the end of 6 months)
Hassan et al. [18]	1995	15 mg/kg im daily for 4 wks.	14/14 (100%)	Not assessed; however, there were no relapses in 1-year follow-up.
Hailu et al. [16]	2010	15 mg/kb body wt. im for 21 days	67.4% (Um el Kher, Sudan = 33.3%, Kassab, Sudan = 60%, Kenya = 86.7%, Gondar, Ethiopia = 66.7%, Arba Minch, Ethiopia = 96.7%) (p value < 0.001)	63.8% (Um el Kher, Sudan = 14.3%, Kassab, Sudan = 46.7%, Kenya = 80%, Gondar, Ethiopia = 75%, Arba Minch, Ethiopia = 96.6%) (p value < 0.001)
Jamil et al. [19]	2015	11 mg/kg BW im once daily for 21 days	98.3%	94.2%
Jha et al. [20]	1998	12, 16, or 20 mg/kg/day for 21 days	12 mg/kg/day group = 90%, 16 mg/kg/day group = 93.3%, 20 mg/kg/day group = 90%	12 mg/kg/day = 77% (n = 23), 16 mg/kg/day = 93% (n = 28), 20 mg/kg/day = 97% (n = 29)
Musa et al. [21]	2010	20 mg/kg/day for 21 days, 15 mg/kg/day for 28 days	20 mg/kg/day group = 85.7% (95% CI), 15 mg/kg/day group = 90.5% (95% CI)	20 mg/kg/day group = 80% (95% CI), 15 mg/kg/day group = 81% (95% CI)
Sinha et al. [22]	2011	11 mg/kg/day for 21 days	99.6% (95% CI)	94.2% (95% CI)
Sundar et al. [1]	2007	11 mg/kg/day for 21 days	98.6%	94.6%
Sundar et al. [23]	2009	Group A = 11 mg/kg/day for 14 days (n = 217); group B = 11 mg/kg/day for 21 days (n = 112)	Group A = 91.2%, group B = 96.4%	Group A = 82%, group B = 92%