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. 2021 Jul 24;2021:5574207. doi: 10.1155/2021/5574207

Figure 2.

Figure 2

Celastrol inhibited the production of IL-1β, IL-6, and TNFα messenger RNA (mRNA) expression levels and contents and upregulated IL-4 and IL-10 messenger RNA (mRNA) expression levels and contents. (a–c) Aβ25-35 increased the expression levels of IL-1β, IL-6, and TNFα (mRNA) from the CA1 region relative to the sham group, whereas CEL downregulated their expression levels. Data are represented as mean ± SD (n = 4). ∗∗p < 0.001 vs. sham group and #p < 0.05 vs. Aβ25-35 group. (d, e) Aβ25-35 decreased the expression levels of IL-4 and IL-10 (mRNA), whereas CEL increased their expression levels. Data are represented as mean ± SD (n = 4). ∗p < 0.001 vs. sham group and #p < 0.05 and ##p < 0.01 vs. Aβ25-35 group. (f–h) Aβ25-35 increased the contents of IL-1β, IL-6, and TNFα from CA1 region, whereas CEL downregulated their expression levels. Data are represented as mean ± SD (n = 4). ∗∗p < 0.01 and ∗∗∗p < 0.001 vs. sham group and #p < 0.05 vs. Aβ25-35 group. (i, j) Aβ25-35 decreased the expression of IL-4 and IL-10 contents, whereas CEL increased their levels. Data are represented as mean ± SD (n = 4). ∗∗∗p < 0.001 vs. sham group and #p < 0.05 and ##p < 0.01 vs. Aβ25-35 group.