Figure 5.

Mechanistic network of miR-223-associated genes at 14 days after PNI

For network shapes, inverted trapezoids indicate miRNA, ovals indicate transcription regulators, and dual rings indicate complexes/groups. For relationships, orange lines indicate activation, gray lines indicate that an effect was not predicted, solid lines indicate a direct relationship, and dotted lines indicate an indirect relationship. For relationship labels, A indicates activation, LO indicates localization, RB indicates regulation of bindings, L indicates molecular cleavage (includes degradation for chemicals), and numbers in brackets indicate numbers of relationships identified by IPKB. Genes in orange indicate predicted activation. Bold-type letters below genes indicate expression level and P-value according to sequencing data. NFκB1: Nuclear factor kappa b subunit 1; PNI: peripheral nerve injury; SMAD3: SMAD family member 3; STAT3: signal transducer and activator of transcription 3.