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. 2021 Jan 25;16(9):1740–1750. doi: 10.4103/1673-5374.306062

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Copyright: © 2021 Neural Regeneration Research

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Reported mechanisms of neuroprotection/neuro-repair activated in different pathologies after topical administration of purified NGF.

Besides its selective effect on cholinergic neurons (affected in Alzheimer’s disease), NGF also triggers neuroprotection-neuro-repair by increasing tissue perfusion/metabolism (brain injury, posterior segment of the eye), and/or eliciting anti-inflammatory response, both directly, via the TrkA activation, and indirectly, by enhancing acetylcholine uptake in monocytes/macrophages. IL: Interleukin; NGF: nerve growth factor; TNF: tumor necrosis factor.