Table 2.
Levels of cytokines/chemokines (relative units/mL) in the peripheral blood serum of rats after intraneural administration of the plasmid pBud-coVEGF165-coFGF2 or the introduction of PBS
| Cytokine/chemokine | 7 days after PBS administration | 7 days after plasmid DNA administration |
|---|---|---|
| MIP-1α | 226.53±78.47 | 16.58±2.81* |
| IL-10 | 640.88±203.54 | 82.98±155.71** |
| IL-12p75 | 251.94±82.24 | 12.20±0** |
| IL-5 | 45.21±15.4 | 4.90±0** |
| TNF-α | 119.31±29.57 | 2.40±0** |
| IL-1α | 1744.27±798.40 | 470.15±170.16** |
| IL-1β | 369.17±125.96 | 109.28±60.95** |
| IL-18 | 1356.42±367.33 | 737.05±196.84** |
| VEGF | 382.54±61.08 | 70.06±4.67** |
| Fractalkine | 328.64±78.36 | 27.50±5.95** |
| RANTES | 2085.34±465.66 | 4065.98±456.40* |
| EGF | 154.60±46.78 | 201.61±50.16* |
| IL-2 | 11.79±2.36 | 39.07±32.88* |
| MCP-1 | 923.39±300.15 | 1138.39±161.96* |
| Eotaxin | 0.89±0.28 | 1.06±0.74 |
| G-CSF | 4.90±0 | 4.90±0 |
| GM-CSF | 12.20±0 | 12.20±0 |
| Leptin | 11041.29±2188.76 | 13464.47±4308.26 |
| IL-4 | 4.90±0 | 4.90±0 |
| IL-6 | 73.20±0 | 73.20±0 |
| IL-13 | 4.90±0 | 4.90±0 |
| IFNγ | 14.6±0 | 14.6±0 |
| IL-17A | 7.30±0 | 7.30±0 |
| IP-10 | 339.78±73.65 | 345.84±34.77 |
| GRO | 14.60±0 | 14.60±0 |
| LIX | 2686.88±688.60 | 2231.09±301.99 |
| MIP-2 | 24.40±0 | 25.46±2.13 |
*P < 0.05, **P < 0.01, vs. 7 days after PBS administration. EGF: Epidermal growth factor; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; GRO: growth-regulated oncogene; IFNγ: interferon-γ; IL: interleukin; LIX: MCP-1: monocyte chemoattractant protein 1; MIP-1α: macrophage inflammatory protein; MIP- 2; macrophage inflammatory protein 2; RANTES: Regulated upon Activation, Normal T Cell Expressed and Presumably Secrete; TNFα: tumor necrosis factor alpha; VEGF: vascular endothelial growth factor.