Table 3.
Mucin-related GEMMs for MCC study
| Gene | Allele symbol | Allele attributes | Reported phenotypes | Reference |
|---|---|---|---|---|
| Muc1 | Muc1<em1Smoc> | Null/knockout | No abnormal phenotype observed | Shanghai Model Organisms Center |
| Muc1<tm1(cre/ERT2)Lcm> | Inducible recombinase | No abnormal phenotype observed | Kopinke and Murtaugh, 2010 BMC Dev Biol | |
| Muc1<tm1(KOMP)Vlcg> | Null/knockout, reporter | No abnormal phenotype observed | Velocigene MGI Direct Data Submission | |
| Muc1<tm1.1(cre/ERT2)Lcm> | Inducible recombinase | No abnormal phenotype observed | Kopinke and Murtaugh, 2010 BMC Dev Biol | |
| Muc1<tm1a(EUCOMM)Wtsi> | Conditional ready, null/knockout, reporter | No abnormal phenotype observed | Skarnes et al., 2011 Nature | |
| Muc1<tm1e(EUCOMM)Wtsi> | Null/knockout, reporter | No abnormal phenotype observed | Skarnes et al., 2011 Nature | |
| Muc1<tm1Gend> | Null/knockout | Digestive/alimentary, homeostasis, liver/biliary, neoplasm | Spicer et al., 1995 J Biol Chem | |
| Muc1<tm1Smoc> | Conditional ready | No abnormal phenotype observed | Shanghai Model Organisms Center | |
| Muc2 | Muc2<eey> | Chemically induced (ENU) | Cellular, digestive/alimentary, endocrine/exocrine, hematopoietic, immune, mortality/aging | Heazlewood et al., 2008 PLoS Med |
| Muc2<keny> | Chemically induced (ENU) | Digestive/alimentary, immune | The Australian Phenomics Facility at The Australian National University | |
| Muc2<M1Btlr> | Chemically induced (ENU) | Digestive/alimentary, immune | Brandl K et al., MGI Direct Data Submission | |
| Muc2<m2Btlr> | Chemically induced (ENU) | Digestive/alimentary, immune | Brandl K et al., MGI Direct Data Submission | |
| Muc2<m3Btlr> | Chemically induced (ENU), no specific | Digestive/alimentary, immune | McAlpine W et al., MGI Direct Data Submission | |
| Muc2<tm1a(KOMP)Wtsi> | Conditional ready, null/knockout, reporter | No abnormal phenotype observed | Skarnes et al., 2011 Nature | |
| Muc2<tm1Avel> | Null/knockout | Velcich et al., 2002 Science | ||
| Muc2<tm1e(KOMP)Wtsi> | Null/knockout, reporter | No abnormal phenotype observed | Skarnes et al., 2011 Nature | |
| Muc2<wnn> | Chemically induced (ENU) | Cardiovascular, cellular, digestive/ alimentary, endocrine/exocrine, growth/size/body, hematopoietic, homeostasis, immune, mortality/aging | Robinson et al., 2017 Am J Physiol Gastrointest Liver Physiol | |
| Muc5ac | Muc5ac<em1Smoc> | Null/knockout | No abnormal phenotype observed | Shanghai Model Organisms Center |
| Muc5ac<tm1.1Evns> | Null/knockout | Digestive/alimentary, homeostasis, immune, vision/eye | Morgan et al., 2021 Nat Commun | |
| Muc5ac<tm2a(EUCOMM)Hmgu> | Conditional ready, null/knockout, reporter | No abnormal phenotype observed | Helmholtz Zentrum Muenchen GmbH | |
| Muc5ac<tm2b(EUCOMM)Hmgu> | Null/knockout, reporter | No abnormal phenotype observed | International Knockout Mouse Consortium | |
| Muc5ac<tm2e(EUCOMM)Hmgu> | Null/knockout, reporter | No abnormal phenotype observed | Helmholtz Zentrum Muenchen GmbH | |
| Muc5b | Muc5b<em1(IMPC)Mbp> | Null/knockout | No abnormal phenotype observed | International Mouse Phenotyping Consortium (IMPC) Database Release |
| Muc5b<Gt(EUCE0173a08)Hmgu> | Gene trapped | No abnormal phenotype observed | Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) | |
| Muc5b<tm1(NCOM)Mfgc> | Null/knockout, reporter | No abnormal phenotype observed | Mammalian Functional Genomics Centre | |
| Muc5b<tm1.2Evns> | Null/knockout | Cellular, growth/size/body, hearing/vestibular/ear, hematopoietic, homeostasis, immune, mortality/aging, respiratory | Roy et al., 2014 Nature | |
| Muc6 | Muc6<tm1(Hbegf)Koo> | Inserted expressed sequence, reporter | No abnormal phenotype observed | Han et al., 2019 Cell Stem Cell |
| Muc16 | Muc15<tm1Lex> | Null/knockout | No abnormal phenotype observed | Tang et al., 2010 Nat Biotechnol |
| Muc16<em1Smoc> | Null/knockout | No abnormal phenotype observed | Shanghai Model Organisms Center | |
| Muc16<m1Mhda> | Null/knockout | No abnormal phenotype observed | Sabrautzki S et al., MGI Direct Data Submission | |
| Muc16<tm1Bhr> | Null/knockout | Reproductive | Shirai et al., 2014 Invest Ophthalmol Vis Sci | |
| Muc16<tm1Bhr> | Null/knockout | No abnormal phenotype observed | Tang et al., 2010 Nat Biotechnol |