Table 1:
Comparison of demographic characteristics and vulvovaginal symptom severity at enrollment according to symptom improvement during the trial.
| Non-responders (n = 60) | Responders (n = 60) | P value | |
|---|---|---|---|
| Age (years): mean ± SD | 61 ± 4 | 61 ± 4 | * |
| White | 55 (92%) | 55 (92%) | * |
| Sexually active within the past month (yes/no) | 51 (85%) | 47 (78%) | 0.35 |
| MENQOL (1-8): mean ± SD | 3.2 ± 1.0 | 3.4 ± 1.2 | 0.49 |
| MBS type | * | ||
| Dryness | 13 (22%) | 14 (23%) | |
| Pain with penetration | 33 (55%) | 33 (55%) | |
| Itching/Irritation/Soreness | 14 (23%) | 13 (22%) | |
| MBS severity (0-3) | 0.02 | ||
| Mean ± SD | 2.4 ± 0.6 | 2.6 ± 0.53 | |
| Median (IQR) | 2 (2, 3) | 2 (2, 3) | |
| VMI < 5% superficial cells | 48 (94%) | 48 (94%) | 0.72 |
| Vaginal pH (median, IQR) | 7.0 (6.0, 7.5) | 7.5 (7.0, 7.5) | 0.02 |
| Severity of symptoms (whether or not chosen as MBS) | |||
| Pain with penetration | |||
| Mean ± SD | 2.0 ± 1.1 | 2.2 ± 0.9 | 0.36 |
| Median (IQR) | 2 (2, 3) | 2 (2, 3) | |
| Dryness | |||
| Mean ± SD | 2.0 ± 0.8 | 2.2 ± 0.8 | 0.14 |
| Median (IQR) | 2 (2, 3) | 2 (2, 3) | |
| Number of moderate/severe symptoms | |||
| 1 | 6 (10%) | 2 (3%) | 0.41 |
| 2 | 17 (28%) | 16 (27%) | |
| 3 | 16 (27%) | 18 (30%) | |
| 4 | 13 (22%) | 19 (32%) | |
| 5 | 8 (13%) | 5 (8%) | |
*
Groups were matched on these criteria
SD = standard deviation, MENQOL= Menopause Quality of Life, MBS = most bothersome symptom, IQR = inter-quartile range