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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Transl Res. 2021 Mar 9;235:32–47. doi: 10.1016/j.trsl.2021.03.005

Fig 5.

Fig 5.

Terazosin treatment abrogates contrast-induced gene expression of Endothelin-1 (Edn1) and Endothelin converting enzyme 1 (Ece-1) in kidneys. Gene expression of Edn1 (A and B) and Ece1 (C and D) were assessed by qRT-PCR in kidneys of mice at day 2 (D2) and day 7 (D7) after contrast administration. There is a significant increase in Edn1 and Ece1 expression at day 2 after CI group compared to S group kidney cortex and day 7 in kidney medulla. Terazosin administration (CI+T) abrogated Edn1 and Ece1 expression in the cortex and in medulla. S, mice with saline administration IP; CI, mice with contrast administration; CI + T, mice with contrast administration plus terazosin IP injection. ANOVA with repeated measurements was performed with post hoc Student t-test. Each bar represents mean ± SEM of 5–7 animals per group. * indicates P < 0.05.