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. 2021 Aug 2;11:15583. doi: 10.1038/s41598-021-95131-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma concentrations of either, BDNF or NT-3 in the sample according to education level and cognitive impairment evaluated using a two-way ANCOVA with "educational level" as a factor and "age" and "BMI” as covariates. Figure (A) shows that BDNF concentrations were not influenced by educational level. Figure (B) shows statistically significant differences in 3-NT concentrations between primary and university education levels. Figure (C) shows statistically significant differences in BDNF concentrations between patients with and without cognitive impairment. Figure (D) shows that NT-3 concentrations were not influenced by cognitive impairment. The bars are estimated marginal means and 95% confidence intervals. *p < 0.05. CI cognitive impairment.