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. 2021 Aug 2;11:15583. doi: 10.1038/s41598-021-95131-2

Table 2.

Variables associated with alcohol consumption and psychiatric comorbidity.

Variables Patients with alcohol use disorder
Total sample
N = 262
Subcohort
N = 58
Statisticsa df p-value
Age at onset of consumption [mean (SD)] (years) 16.26 (3.9) 15.17 (2.95) 1.670b 314 0.096
Age at the development of dependence [mean (SD)] (years) 29.56 (10.62) 31.23 (11.07) − 0.946b 347 0.339
Length of AUD diagnosis [mean (SD)] (years) 15.35 (10.41) 16.36 (14.93) − 0.051b 295 0.964
Severity criteria [mean (range)]
Criteria (0–11) 7.46 (2.19) 7.88 (2.08) − 1.285b 316 0.200
Duration of abstinence [Mean (mode)] (Days) 306.67 (60) 128.61 (60) 2.443b 312 0.003
Comorbid substance use disorders [N (%)]
Cocaine 77 (29.4) 19 (32.8) 0.326c 1 0.633
Cannabis 34 (13) 6 (10.3) 0.266 0.825
Sedatives 18 (6.9) 5 (8.6) 0.245 0.579
Comorbid psychiatric disorders N (%)]
Mood 119 (45.4) 25 (43.1) 0.024c 1 1
Anxiety 81 (30.9) 20 (34.5) 0.441 0.529
Personality 43 (16.4) 5 (8.6) 2.071 0.221
ADHD 54 (20.6) 6 (10.3) 3.028 0.217
Psychiatric medication use [N (%)]
Antidepressants 114 (43.5) 31(53.4) 1.821c 1 0.189
Anxiolytics 103 (39.3) 19 (32.8) 0.933 0.370
Anticraving 71 (27.1) 19 (32.8) 0.713 0.420
Disulfiram use [N (%)] 168 (64.1) 45 (77.6) 0.704c 1 0.590

df degree of freedom.

Bold values are statistically significant for p < 0.05.

aThe statistical analysis was conducted using the logarithmic transformed values to ensure that statistical assumptions were met for age at the onset of consumption, age at the development of dependency, duration AUD, severity criteria met and duration of abstinence.

bStudent’s t test statistic.

cChi-square test statistic.