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. 2021 Apr 29;125(3):337–350. doi: 10.1038/s41416-021-01394-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative results from GBM_WSSM application on the TCGA samples. (i) WSIs from TCGA. (ii) Corresponding masks produced by GBM_WSSM. b Measurement of different tumour regions (normalised) and patient survival in each TCGA glioblastoma case. c Dot plot graph of the results shown in b. d Pearson correlation values between survival rates and normalised areas corresponding to each tumour region (asterisk denotes p < 0.05). Comparable statistically significant results were obtained in the presence or absence of outliers using Spearman correlation analysis, which is less sensitive to the presence of outliers. e Distribution of glioblastoma patients harbouring specific oncogenic mutations in TCGA. f Heatmap plot of Pearson correlation values between the size of the tumour regions and survival rates.