Table 4.

Recent guidelines and recommendations on LT for CRLMs.

ILTS transplant oncology consensus conference (74)	Grade of recommendation	Recommendations by the Spanish Society of Liver Transplantation (73)	Grade of recommendation
LT can be a viable option in highly selected patients with unresectable CRLM with only liver involvement	moderate evidence and moderate recommendation	In selected patients with unresectable liver metastases of colorectal cancer, LT could be considered only in the context of well-designed clinical trials and after a close evaluation by a multidisciplinary team composed by oncologists, hepatologists, and surgeons.	2B
LT for CRLM with low Oslo score ≤2 may improve the 5-year OS rates over those achieved with the current standard of care	moderate evidence and moderate recommendation	The optimal strategy for waiting list prioritization is not established and should be tailored according to the composition and length of the waiting list in each region.	2C
Minimization of immunosuppression is recommended	low evidence and moderate recommendation	The type of donor would be at the discretion of each transplant center according to local experience and length of stay in the waiting list.	2C
Aggressive treatment of all post-LT resectable recurrences is recommended	low evidence and moderate recommendation
There is a need for an international registry to coordinate data collection and design further studies on LT for CRLM	moderate evidence and moderate recommendation

CRLM, Colon Rectal Liver Metastases; LT, Liver Transplantation; OS, Overall Survival.