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. 2021 Feb 3;473(9):1393–1410. doi: 10.1007/s00424-021-02523-4

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© The Author(s) 2021, corrected publication 2021

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Fig. 5 — RetGC-binding interface in GCAP1. The surface-exposed residues critical for the regulatory binding to RetGC are highlighted in red, and the non-essential residues are highlighted in blue [92]. The main part of the binding interface on GCAP1 occupies EF-hand 1 and 2 in semi-globule I, whereas the most critical Ca²⁺ sensor function belongs to the semi-globule II containing EF-hands 3 and 4