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A proposed biological role of RD3 in photoreceptors [31, 74, 95]. RD3 stimulates the delivery of RetGC to the outer segment while blocking its activation by GCAPs in the inner segment. In RD3-deficient photoreceptors, the content of RetGC in the outer segment declines and the photoresponses become compromised due to insufficient production of cGMP; aberrant activation of the unprotected RetGC occurs in the inner segment and triggers degeneration of the photoreceptor cell
