Table 4.

The Pharmacokinetics ADME Properties of Selected Imidazole Derivatives as Anti-Cancer Agents

Compounds Codes	Molecular Weight	HB Donor	HB Acceptor	Log Po/w (WLOGP)	Log S (SILICO S-IT)	BBB Permeant	GI Absorption	Rule of Five (ROF)
Imidazole Derivatives as Anti-Cancer
C1	360.84 g/mol	2	3	4.18	−6.12 Poorly soluble	Yes	High	Yes; 0 violation
C2	739.04 g/mol	2	5	7.36	−12.75 Insoluble	No	Low	Yes; 1 violation: MW>500
C3	388.43 g/mol	4	5	2.28	−6.84 Poorly soluble	No	High	Yes; 0 violation
C4	372.93 g/mol	1	2	6.39	−8.42 Poorly soluble	No	High	Yes; 0 violation
C5	269.17 g/mol	0	1	4.77	−4.86 Moderately soluble	Yes	High	Yes; 0 violation
C6	366.60 g/mol	2	3	3.23	−6.46 Poorly soluble	Yes	High	Yes; 0 violation
C7	447.28 g/mol	0	5	3.75	−5.97 Moderately soluble	Yes	High	Yes; 0 violation
C8	408.27 g/mol	0	5	4.32	−6.59 Poorly soluble	No	High	Yes; 0 violation
C9	294.31 g/mol	4	6	−1.48	−2.02 Soluble	No	Low	Yes; 0 violation
C10	490.60 g/mol	0	2	7.50	−12.48 Insoluble	No	Low	Yes; 0 violation
C11	365.22 g/mol	1	3	5.63	−9.22 Poorly soluble	Yes	High	Yes; 0 violation
C12	460.53 g/mol	2	6	2.44	−7.50 Poorly soluble	No	High	Yes; 0 violation
C13	607.65 g/mol	3	9	8.66	−12.88 insoluble	No	Low	Yes; 1 violation: MW>500
C14	586.66 g/mol	2	6	5.87	−10.64 insoluble	No	Low	No; 1 violation: MW>500
C15	437.66 g/mol	2	2	7.84	−10.19 Insoluble	No	Low	Yes; 0 violation
C16	390.39 g/mol	1	5	2.50	−5.09 Moderately soluble	No	High	Yes; 0 violation
C17	365.81 g/mol	1	2	3.13	−6.33 Poorly soluble	Yes	High	Yes; 0 violation