Table 9.
Compounds Codes | GPCR Ligand | Ion Channel Modulator | Kinase Inhibitor | Nuclear Receptor Ligand | Protease Inhibitor | Enzyme Inhibitor | Reported Target | Reference |
---|---|---|---|---|---|---|---|---|
Imidazole Derivatives as Anti-inflammatory | ||||||||
I30 | 0.42 | 0.32 | 0.67 | −0.10 | 0.12 | 0.24 | COX-2 enzyme | [45] |
I31 | 0.17 | 0.08 | 0.48 | −0.23 | −0.25 | 0.32 | COX-1,2 5-LOX, sPLA2-V Inhibition |
[50] |
I32 | −0.12 | −0.55 | −0.27 | −0.56 | −0.61 | −0.24 | COX-2 enzyme | [47] |
I33 | 0.05 | −0.06 | −0.19 | 0.02 | −0.24 | 0.21 | p65 NF-κB |
[49] |
I34 | 0.64 | 0.15 | 0.26 | 0.03 | 0.28 | 0.72 | NF-κB | [48] |
I35 | 0.05 | 0.07 | 0.04 | −0.28 | −0.41 | 0.00 | ND | [35] |
I36 | 0.21 | 0.12 | 0.18 | −0.15 | −0.29 | 0.16 | ND | [35] |
I37 | −0.13 | 0.09 | 0.08 | −0.69 | −0.44 | −0.07 | ND | [44] |
I38 | −0.10 | −0.57 | −0.58 | −054 | −0.50 | −0.23 | ND | [46] |
I39 | −0.11 | −0.19 | 0.07 | −0.36 | −0.23 | −0.14 | ND | [51] |