. 2021 Aug 2;11:15652. doi: 10.1038/s41598-021-95154-9

Table 1.

Annotations for top GWAS loci associated with circulating kynurenine levels derived from the KORA-TwinsUK meta-analysis GWAS summary statistics.

SNP	Chromosome	Position	Reference allele	Alternative allele	Reference allele frequency	Beta	SE	P value	Closest gene (s)	Genomic location	eQTL (s)^a	Possible relationship to kynurenine
rs10085935	8	39,806,267	T	C	0.37	− 0.010	0.002	3.326E−09	IDO2	intronic	IDO1	✓
rs16924894	10	24,845,525	A	T	0.02	0.081	0.015	2.329E−08	KIAA1217 (dist = 8748), ARHGAP21 (dist = 27,013)	intergenic	No significant eQTLs were found
rs3184504	12	111,884,608	T	C	0.48	0.015	0.002	6.046E−18	SH2B3	exonic-Missense (R262W)	ALDH2, LINC01405, TMEM116, ADAM1B, MAPKAPK5-AS1	✓
rs11066320	12	112,906,415	A	G	0.43	0.012	0.002	3.101E−11	PTPN11	intronic	ALDH2, ADAM1B, MAPKAPK5, NAA25, BRAP
rs750950	16	87,873,247	A	C	0.64	0.014	0.002	2.342E−16	SLC7A5	intronic	SLC7A5	✓
rs8051149	16	87,878,822	A	G	0.21	0.026	0.003	9.073E−26	SLC7A5	intronic	SLC7A5, RP4-536B24.2	✓

Data was obtained from http://metabolomics.helmholtz-muenchen.de/gwas/. Four shading rows indicate SNPs belonging to 4 independent regions.

SNP single nucleotide polymorphism, SE standard error.