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. 2021 Aug 2;5:20. doi: 10.1038/s41538-021-00102-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The relative mRNA expression levels of Ar, Tmprss2, and Ace2 in prostate (n = 3), lungs (n = 3), small intestine (n = 3), and kidneys (n = 3) in 8-week-old male C57BL/6 mice were quantified by qRT-PCR. qPCR values (mean ± SD) are expressed as mRNA copies/µg total RNA. b The mRNA expression levels of AR, TMPRSS2, and ACE2 in the prostate (n = 152), lungs (n = 427), small intestine (n = 137), and kidneys (n = 45) in adult humans were extracted from the “The Human Protein Atlas/The Genotype-Tissue Expression (GTEx) Dataset”. GTEx dataset reports mRNA expression of each gene in human tissue as average pTPM. The data were presented by box plots showing all values. c The localization of AR, TMPRSS2, and ACE2 in the prostate, lungs, small intestine, and kidneys in 8-week-old male C57BL/6 mice were displayed by immunohistochemistry (IHC). d The IHC images of AR, TMPRSS2, and ACE2 in the prostate, lungs, small intestine, and kidneys in adult humans were extracted from the “The Human Protein Atlas/Protein Expression Summary” subcategory. In the database of The Human Protein Atlas, IHC staining was performed on normal human tissue. The scale bar of representative images is ×40 by 100 μm.