Skip to main content
. 2021 Aug 2;5:20. doi: 10.1038/s41538-021-00102-6

Fig. 2. WBM suppresses DHT-induced AR-TMPRSS2 expression in multiple mouse organs.

Fig. 2

a Eight-week-old male C57BL/6 mice were subcutaneously grafted pellets (3 mice with placebo pellets versus 12 mice with DHT pellets). The 3 mice with placebo pellets were gavaged daily with 100 μL PBS for 2 weeks (Placebo group, n = 3). The 12 mice with DHT pellets were randomly divided into 3 groups and treated daily for 2 weeks as follows: 100 μL PBS (DHT group, n = 3), 300 μg enzalutamide (DHT + Enza group, n = 3), and 6 mg WBM (DHT + WBM group, n = 3). b The mRNA levels of Ar, Tmprss2, and Ace2 in the prostate (n = 3), lungs (n = 3), small intestine (n = 3), and kidneys (n = 3) of each group were quantified by qRT-PCR. The target mRNA expression was quantified using the ΔΔCt method, as normalized to Gapdh transcript levels. The results were shown as mean ± SD. p Values were determined with one-way ANOVA (*p < 0.05, **p < 0.01. ns no significant difference).