Table 1.
Patients characteristics.
| Fast metabolizers n = 192 | Slow metabolizers n = 418 | p-value | |
|---|---|---|---|
| Body weight (kg) | 74.7 ± 14.5 | 73.6 ± 14.8 | 0.512a |
| Height (m) | 1.71 ± 0.10 | 1.70 ± 0.09 | 0.508a |
| BMI (kg/m2) | 24.7 (22.1–27.4) | 24.5 (22.6–27.1) | 0.810c |
| Age (years) | 52.5 ± 14.3 | 56.0 ± 11.8 | 0.003a |
| Sex (m/f, %) | 120 (62.5%) / 72 (37.5%) | 266 (64%) / 152 (36%) | 0.787b |
| Living donor transpl. | 14 (7.3%) | 23 (5.5%) | 0.465b |
| Cadavaric donor transpl. | 178 (92.7%) | 395 (94.5%) | |
| HBD | 155 (80.7%) | 340 (81.3%) | 0.728b |
| NHBD I | 19 (9.9%) | 42 (10%) | |
| NHBD II | 1 (0.5%) | 0 | |
| NHBD III | 17 (8.9%) | 35 (8.4%) | |
| NHBD IV | 0 | 1 (0.2%) | |
| ESP transpl. | 8 (4.2%) | 3 (0.7%) | 0.006b |
| ABO-incompatible transpl. | 0 | 2 | – |
| Cold ischemia time (h) | 12.1 ± 5.8 | 12.5 ± 5.8 | 0.525a |
| Delayed graft function | 32 (16.7%) | 77 (18.4%) | 0.650b |
| KDPI | 49.0 ± 25.8 | 47.0 ± 25.4 | 0.402a |
| Warm ischemia time (min) | 35 (30–41) | 35 (30–45) | 0.262c |
| HLA MM | |||
| 0 | 8 (4.2%) | 28 (6.7%) | 0.393b |
| 1–3 | 117 (60.9%) | 240 (57.4%) | |
| 4–6 | 59 (30.7%) | 140 (33.5%) | |
| PRA > 20% | 13/177 (6.8%) | 27/394 (6.5%) | 0.860b |
| Combined transpl. | |||
| + Pancreas | 4 (2.1%) | 12 (2.9%) | 0.695b |
| + Liver | 3 (1.6%) | 3 (0.7%) | |
| + Heart | 0 | 1 (0.2%) | |
| Non-combined | 185 (96.4%) | 402 (96.2%) | |
| Donor characteristics | |||
| Donor age (years) | 49.7 ± 16.0 | 49.0 ± 15.1 | 0.601a |
| Donor sex (m/f) % | 82 (52%) / 76 (48%) | 196 (51%) / 188 (49%) | 0.925b |
| Donor height (m) | 1.71 ± 0.09 | 1.72 ± 0.09 | 0.326a |
| Donor weight (kg) | 74.1 ± 14.8 | 74.6 ± 14.4 | 0.718a |
| Donor BMI (kg/m2) | 24.7 (22.6–26.6) | 24.8 (22.5–26.8) | 0.936c |
Data presented as mean ± standard deviation or median (25% quantile-75% quantile), or absolute and relative frequencies.
BMI body mass index, transpl. transplantation, HBD heart-beating donors, NHBD non-heart-beating donors (only from the Leuven-cohort), ESP European Senior Program, KDPI kidney donor profile index, HLA MM human leucocyte antigen mismatch, PRA panel reactive antibodies.
aWelch's t-test.
bFisher's exact test.
cMann–Whitney U test.