Table 2.
Doses, Tac trough level, Tac C/D ratio.
| Fast metabolizers n = 192 |
Slow metabolizers n = 418 |
p-value | |
|---|---|---|---|
| 1 month after RTx | |||
| Tac daily dose (mg) | 16 (12.0–21.0) | 9 (7–12) | < 0.001a |
| Tac trough level (ng/mL) | 11.0 (9–13) | 12.1 (10.2–15) | < 0.001a |
| Tac C/D ratio | 0.69 (0.52–0.91) | 1.4 (1.0–1.89) | < 0.001a |
| Prednisone dose | 15 (12.5–20) | 15 (10.6–20) | 0.940a |
| Methylprednisolone | 12 (9.5–16) | 12 (8–12) | 0.006a |
| 3 months after RTx | |||
| Tac daily dose (mg) | 14 (11–18) | 7 (5–9) | < 0.001a |
| Tac trough level (ng/mL) | 10.0 (8.0–11.0) | 11.0 (9.3–13.0) | < 0.001a |
| Tac C/D ratio | 0.72 (0.54–0.83) | 1.60 (1.25–2.18) | < 0.001a |
| Prednisone dose | 10 (5–15) | 5 (5–7.5) | 0.117a |
| Methylprednisolone | 4 (4–4) | 4 (4–4) | 0.229a |
| 6 months after RTx | |||
| Tac daily dose (mg) | 11 (9–15) | 6 (4–7.4) | < 0.001a |
| Tac trough level (ng/mL) | 9.9 (7.1–11.9) | 9.4 (6.0–14.0) | < 0.916a |
| Tac C/D ratio | 0.89 (0.63–1.08) | 1.69 (1.29–2.33) | < 0.001a |
| Prednisone dose | 5 (2.5–10) | 5 (1.3–5) | 0.172a |
| Methylprednisolone | 4 (4–4) | 4 (4–4) | 0.835a |
| Initial co-immunosuppression | |||
| Mycophenolate mofetil, n (%) | 190 (99.3%) | 415 (99%) | 0.652b |
| Mycophenolate sodium, n (%) | 2 (0.7%) | 3 (1%) | |
Data presented as mean ± standard deviation or median (25% quantile-75% quantile), or absolute and relative frequencies.
Tac tacrolimus, C/D concentration to dose.
aMann–Whitney U test.
bFisher’s exact test.