Table 3.
Renal function, eGFR (linear mixed model).
| Model-based estimates | |||||
|---|---|---|---|---|---|
| Mean eGFR | Lower 95% confidence limit | Upper 95% confidence limit | p-value | ||
| ESP transplantation | Yes vs. no | −5.73 | −12.23 | 0.77 | 0.084 |
| Age at RTx | x vs. x − 1 years | −0.36 | −0.46 | −0.26 | < 0.001 |
| Effect of metabolism group combined over all time points | Fast vs. slow | −7.5 | −10.6 | −4.3 | < 0.001 |
| Effect of time combined over both metabolism groups | < 0.001 | ||||
| Interaction term of ER-Tac metabolism groups × time points | 0.037 | ||||
| Least square estimates of the mean difference between fast and slow metabolizer at different time points (combination of main and interaction effects of tacrolimus metabolism group and time points) | |||||
| At 3 months | Fast vs. slow | −7.62 | −10.70 | −4.55 | < 0.001 |
| At 6 months | Fast vs. slow | −6.98 | −10.55 | −3.42 | < 0.001 |
| At 12 months | Fast vs. slow | −8.51 | −11.85 | −5.18 | < 0.001 |
| At 24 months | Fast vs. slow | −8.22 | −11.69 | −4.75 | < 0.001 |
| At 36 months | Fast vs. slow | −9.04 | −12.83 | −5.25 | < 0.001 |
| At 48 months | Fast vs. slow | −7.07 | −11.20 | −2.95 | < 0.001 |
| At 60 months | Fast vs. slow | −4.80 | −9.03 | −0.56 | 0.027 |
| Least square estimates of the mean change between the time points for each metabolism group (combination of main and interaction effects of tacrolimus metabolism group and time points) | |||||
| Fast metabolizer | 6 vs. 3 months | 5.18 | 3.22 | 7.13 | < 0.001 |
| 12 vs. 3 months | 4.08 | 2.11 | 6.05 | < 0.001 | |
| 24 vs. 3 months | 2.92 | 0.76 | 5.09 | 0.008 | |
| 36 vs. 3 months | 2.16 | −0.27 | 4.60 | 0.082 | |
| 48 vs. 3 months | 2.45 | −0.49 | 5.40 | 0.103 | |
| 60 vs. 3 months | 3.87 | 0.84 | 6.89 | 0.012 | |
| Slow metabolizer | 6 vs. 3 months | 4.54 | 3.09 | 5.98 | < 0.001 |
| 12 vs. 3 months | 4.97 | 3.57 | 6.37 | < 0.001 | |
| 24 vs. 3 months | 3.52 | 1.86 | 5.18 | < 0.001 | |
| 36 vs. 3 months | 3.58 | 1.55 | 5.60 | < 0.001 | |
| 48 vs. 3 months | 1.90 | −0.24 | 4.04 | 0.082 | |
| 60 vs. 3 months | 1.04 | −1.26 | 3..33 | 0.375 | |
Results of the linear mixed model. Selected parameter estimates and least square means for estimated glomerular filtration rate (eGFR) (mL/min/1.73 m2) are shown. P-values are from Wald tests. Repeated measurements for each patient were modelled using SAS PROC MIXED by fitting a marginal linear mixed model with an unstructured variance–covariance matrix for the residuals with patient as subject and the order given by time.
ESP European Senior Program, RTx renal transplantation.