Table 5.
First acute rejection, graft failure and death.
| Fast metabolizers n = 192 | Slow metabolizers n = 418 | p-value | |
|---|---|---|---|
| First acute rejection (from RTx to 3 months after RTx) | 47 (24.5%) | 69 (16.5%) | 0.026a |
| First acute rejection between 3 months and 5 years from RTx (events, 5 year-Est, 95% CI) | 16/145 16.3% (8.3–23.6%) | 17/349 6.8% (3.3–10.1%) | 0.008b |
| Type of first acute rejection (from 3 months to 5 years after RTx) | |||
| ABMR | 0 | 2 | 0.095a |
| TCMR | 7 | 10 | |
| Borderline | 9 | 4 | |
| borderline + ABMR | 0 | 1 | |
| Graft failure as first event between 3 months and 5 years from RTx (events, 5 year-cumulative incidence, 95% CI) |
23 15% (10.2–22.1%) |
56 17.7% (13.9–22.7%) |
0.562c |
| Reasons for graft failure | |||
| Chronic allograft rejection | 5 | 5 | 0.240a |
| Glomerulonephrtis recurrence | 2 | 1 | |
| BKVN | 1 | 4 | |
| Infection | 2 | 11 | |
| Allograft ischemia/renal artery complication | 2 | 4 | |
| Perirenal hematoma | 1 | 0 | |
| Nephrocalcinosis | 0 | 1 | |
| Death with functioning allograft | 10 | 30 | |
| Death 3 months and 5 years from RTx (events, 5 year-Est, 95% CI) |
15 13.0% (6.4–19.0%) |
47 16% (11.5–20.3%) |
0.320b |
| Reasons for death | |||
| Cardiovascular | 2 | 5 | 0.776a |
| Malignancy | 2 | 12 | |
| Infection | 3 | 13 | |
| Encephalopathia | 0 | 1 | |
| Mayor bleeding | 1 | 1 | |
| Intoxication | 0 | 1 | |
| Trauma | 0 | 1 | |
| EuthanasiaA | 0 | 1 | |
| Unknown | 7 | 12 | |
Cumulative incidence was estimated using the Aalen-Johansen estimator.
Est = 1 − Kaplan–Meier estimator, ABMR antibody mediated rejection, TCMR T-cell mediated rejection, BKVN BK virus nephropathy, RTx renal transplantation.
AOnepatient from the Belgian cohort.
P-values: a Fisher’s exact test; bLogrank test; cGray k-sample test.