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. 2021 May 12;125(3):422–432. doi: 10.1038/s41416-021-01400-2

Fig. 1. HLA mRNA expression comparison across cancer types and HLA genes.

Fig. 1

a Heatmap comparing the expression between all HLA/B2M between normal and tumour tissue. Displayed are −log10(p-value) values of t-tests comparing HLA/B2M expression in normal and tumour tissue. P-values were adjusted by the Bonferroni procedure. All adjusted p-values > 0.05 were considered non-significant and set to −log10(p) = 0. P-values received a negative sign if the log2FC between normal and tumour was negative (i.e. higher expression in normal tissue). Values greater than |4| were set to 4. b Median HLA/B2M gene expression by cancer type and HLA gene. c Correlation matrix of HLA/B2M gene expression across all cancer types. d Percentage of variance captured by principal component 1 (PC1) in each cancer type. e Correlation matrix of the meta-HLA gene and gene expression of HLA/B2M. P-values were adjusted by the Bonferroni procedure. All correlations with adjusted p-values > 0.05 were considered non-significant and set to 0. Classical HLA genes indicated with a dot (●), HLA class I genes indicated in blue, HLA class II genes in purple.